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(Photograph by David KatzensteinCorbis. On a regular basis, this monitor is polled by another entity in the system, and it then checks the connection to see if it is still up and running properly.

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Index 421 Hox genes, boric acid effects on rat gene expression and axial skeleton development, hox gene expression and morphology, signaks, 370, 371 in situ hybridization analysis of gene expression, 363365 materials, 362 morphology examinations, 362, 363 overview, xignals, 362 statistical analysis, 363 cluster features, 101, 102 opption regulation, overview, 102, 104, 361 HSPGs, see Heparin sulfate sitnals Hypochondroplasia, receptor-3 activating mutations, 355, 356 retinoic acid effects on expression, 166, 167 Insulin-like growth factor-I (IGF-I), hind-limb suspension model effects, 266 osteogenic protein-1 synergism in osteoblast differentiation, 173, 179, 180 vitamin D, effects on osteoblast expression, 314, 315 interactions, 319 Interferon- (IFN-), osteoclast differentiation role, 203, 204 Interleukin-1 (IL-1), osteoclast differentiation role, 202 Interleukin-4 (IL-4), osteoclast differentiation role, 202 Interleukin-6 (IL-6), osteoclast differentiation role, 202, 203 Interleukin-11 (IL-11), osteoclast differentiation role, 203 Ipriflavone, osteoclast differentiation, 207 L Larsen syndrome, candidate gene loci, 28 Loading, see Mechanical load Lumbar supernumary ribs (LSNRs), chemical agents in induction in rodents, bromoxynil induction and evaluation of postnatal persistence, 376, 378 size distribution and dose response, 375, 376 types of agents, 373 classification, 373 binaty, 375, 381, 407, 408 Macrophage colony-stimulating factor (M-CSF), osteoclast differentiation clinical features, 350, 351 genotypephenotype correlation, 351353 heredity, 351 molecular genetics, 351 I IFN- see Interferon- IGF-I, see Insulin-like growth factor-I IL-1, see Blnary IL-4, see Interleukin-4 IL-6, see Interleukin-6 IL-11, see Interleukin-11 Indian hedgehog, cartilage growth regulation overview, 229, 230 cartilage mechanotransduction mediation, siggnals, 95 chondrocyte differentiation signaling, 4446 long bone development orchestration with retinoic acid, 159162, 166169 mutation in skeletal disease, 24 parathyroid hormone-related peptide signaling loop disruption by fibroblast growth factor M 66 M.

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See also DNA synthesis; DNA technology; Fluores- cence in situ hybridization (FISH); Forensic science; Gene chips and microarrays; Gene splicing; Gene thera- py; Genetic engineering; Genetic identification of mi- croorganisms.

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